Synthesis of 8-Phenoxy-2′-deoxyguanosine Nucleoside Analogues

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Synthesis and properties of oligonucleotides containing 8-bromo-2'-deoxyguanosine.

The preparation of oligonucleotides containing 8-bromo-2'-deoxyguanosine is described. Substitution of G by 8-bromoguanine on an alternating CG decamer stabilizes the Z-form in such a way that the B-form was not observed. Melting temperatures showed that duplexes in which 8-bromo-2'-deoxyguanosine paired with natural bases were much less stable.

Synthesis of ribavirin 2’-Me-C-nucleoside analogues

An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2'-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

Synthesis of 1,2,3- Triazole Nucleoside Analogues

Both 1,2,3-triazoles and nucleosides have proved to be useful pharmacophores for antiviral and anticancer agents. A series of novel 1,2,3-triazole nucleoside analogues were designed and synthesized in order to find new antiviral or antitumor compounds. KEYWORD: Triazole; Nucleoside; Virus; Cancer International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The au...

Convenient synthesis of nucleoside and isonucleoside analogues.

[reaction: see text]. A very simple methodology to stereoselectively achieve tricyclic isonucleosides (nucleobase = thymine, uracil, and 5-fluoruracil) and 3'-C-branched nucleosides (nucleobase = theophylline) was performed by means of a DBU-mediated addition process using a readily available 2-bromo sugar. The mechanism for these transformations implies the loss of both substituents at C-2 and...